Research Laboratories

Nutritional Biochemistry and Liver Diseases Laboratory

Dr. Mike Pagliassotti, Director


Our laboratory uses animal and cell models to explore the role of nutrients in both the development and prevention of obesity-related liver disease. Specific areas currently being studied include: the role of lipids in endoplasmic reticulum stress and mitochondrial dysfunction; characterization of the aging liver with a particular emphasis on proteostasis; novel therapeutic strategies in non-alcoholic fatty liver disease.

Recent Publications

Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view.


  • Director - Dr. Mike Pagliassotti
  • Lab Managers: Dong Wang, PhD and Rosie Wei, MS
  • Collaborators
    • Douglas Seals, PhD, University of Colorado, Boulder
    • Melinda Frye, PhD, Colorado State University
    • Benjamin Miller, PhD, Colorado State University
    • Karyn Hamilton, PhD, Colorado State University